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Yellow Fever (1800s)
In the 1700s and 1800s, yellow fever killed more than 100,000 Americans from New Orleans to Boston. The last epidemic in this country ended in 1905, but yellow fever continues to be a scourge of tropical South America and Sub-Saharan Africa. According to the World Health Organization (WHO), there are roughly 200 new cases of yellow fever each year, resulting in 30,000 deaths. However, few cases are ever positively identified, so the true toll could be even higher.